Pitavastatin and atorvastatin are both lipid-regulating drugs, and due to the different physiques of patients, they have different sensitivities to the drugs, and the adverse reactions to the drugs will also be different. There is no such thing as “which one is safer”, patients should follow the doctor’s instructions to standardize the use of drugs. Pitavastatin is mainly used for the treatment of hypercholesterolemia and familial hypercholesterolemia. Some patients may experience abdominal pain, muscle pain, fatigue, skin rash, itching and other allergic diagnosis in the process of using the drug, and in severe cases, it may lead to thrombocytopenia, liver dysfunction, jaundice, etc. If there is any abnormality during the use of the drug, it is necessary to stop the use of pitavastatin. Any abnormality during the use of the drug needs to be discontinued and properly treated. In addition, patients suffering from liver and kidney diseases, alcoholism, hypothyroidism should use the drug with caution, and pregnant and lactating women should be prohibited from using this drug. Atorvastatin can be used for hypercholesterolemia and also for the treatment of coronary heart disease. Common adverse reactions include diarrhea, nausea, skin rash, etc. A few patients may experience memory loss, confusion, etc., which can usually be recovered after stopping the drug. Serious adverse reactions such as rhabdomyolysis and myalgia may also occur. Once persistent or severe discomfort occurs during the course of medication, prompt medical attention should be sought. Atorvastatin is contraindicated in women with active liver disease, pregnancy and lactation. Both pitavastatin and atorvastatin are prescription medications and should be used under the supervision of a physician if needed to minimize the risk of medication.