Long-term glutamyl transferase 600 may be caused by hepatitis, cirrhosis, intrahepatic cholestasis, etc. Hepatoprotective treatments such as ursodeoxycholic acid, surgery, etc. may be used. 1. Acute and chronic hepatitis, cirrhosis, etc.: the liver cells are damaged, resulting in the release of transferase into the blood and elevation, ursodeoxycholic acid, adenosylmethionine, silymarin, reduced glutathione and other drugs can be used for liver-protecting treatment. At the same time, bed rest is needed, and smoking and alcohol cessation are strictly prohibited. 2. Intrahepatic cholestasis: In addition to the use of the above liver-protecting drugs, surgery can also be used to relieve biliary obstruction and reduce cholestasis. Medications should be used under the guidance of a doctor and early medical attention is recommended.