In neonates with gastrointestinal bleeding, blood volume should be actively expanded and replenished, blood pressure should be maintained, and the basic blood supply to all organs should be ensured. The cause of the bleeding should also be determined, which commonly includes acute stress ulcers complicated by intracranial hemorrhage, primary lesions of the gastrointestinal tract, including ulcers, and, to a lesser extent, tumors. In addition to treatment, hemostatic medications should be given, and intravenous suspension of red blood cells and plasma is an option depending on the results of the laboratory tests. If the condition permits, surgical treatment can be performed to stop the bleeding and remove the primary lesion, but it is risky and can be complicated by organ failure due to organ ischemia during treatment.