The EULAR Task Force on Guidelines for the Treatment of Knee OA reviewed 545 publications on the treatment of knee OA from 1966 to February 2002 and evaluated the efficacy and toxicities of the treatment groups versus the placebo groups provided in the literature. After several rounds of screening and discussion, the working group made 10 recommendations for new guidelines for the treatment of knee OA. The ideal treatment plan for knee OA should include a combination of non-pharmacologic and pharmacologic treatments. 2, knee OA treatment plan should be based on the following factors: a. Knee OA risk factors (obesity, adverse mechanical factors, body mobility). b. General risk factors (age, concomitant disease, overdose). c. Pain intensity and degree of disability. d. Inflammatory manifestations: such as exudation. e. The degree and location of tissue destruction. 3. Non-pharmacologic treatment of knee OA should include patient education, functional exercise, application of assistive devices (canes, insoles, knee braces), and weight reduction. 4. Acetaminophen is preferred, and if effective, can be taken orally for a long time. 5, NSAIDs preparations and capsaicin and other topical drugs are effective and safe for clinical treatment. 6.Oral NSAIDs can be used for patients in whom acetaminophen is not effective. For patients with significant gastrointestinal adverse reactions, non-selective NSAIDs plus effective gastric mucosal protective agents or selective COX-2 inhibitors should be given. 7. For patients in whom NSAIDs are ineffective and/or poorly tolerated, analgesics combined with acetaminophen or used alone are an effective alternative treatment. 8.Dextranamine sulfate, chondroitin sulfate, diacetin, unsaponifiable avocado beans, hyaluronic acid can relieve clinical symptoms, and is beneficial to the repair of joint tissue damage. 9.Intra-articular injection of long-acting adrenocorticotropic hormone is suitable for knee pain, especially for patients with exudation. 10. For patients with persistent joint pain or disability and imaging evidence of knee OA, arthroplasty may be considered. The above recommendations provide a variety of options for the treatment of knee OA, but each patient must be selected for an individualized treatment plan.