RAS is the renin-angiotensin system, sustained excessive RAS activation can induce hypertension, cardiac hypertrophy, congestive heart failure and other pathological processes, there are a variety of drugs to inhibit the RAS in the treatment of cardiovascular disease is widely used, including renin inhibitors, ACEI, ARB, aldosterone antagonists and so on.
1. Renin inhibitors: the drug can reduce plasma renin activity and the level of angiotensin I and II, play a role in lowering blood pressure and treating cardiovascular disease, such as Aliskiren.
2. Angiotensin-converting enzyme inhibitor ACEI: by inhibiting the generation of Ang II, it protects the function of vascular endothelium and cardiomyocytes, which is beneficial to the prevention and treatment of hypertension, heart failure and cardiovascular remodeling, such as captopril and enalapril.
3. Angiotensin II receptor (AT1 receptor) blocking drug ARB: Compared with ACEI, ARB blocks the AT1 receptor of Ang II, which is more specialized and avoids the side effects brought by blocking the AT2 receptor, such as chlorsartan and valsartan.
4. Aldosterone antagonists such as spironolactone.
It should be noted that the medication should be administered under the guidance of a doctor, and should not be used without authorization to avoid adverse effects.