There is no such thing as “the best treatment for Major syndrome”. Commonly used treatments are deep brain electrical stimulation surgery, localized botulinum toxin injections, or oral medications. It all varies from person to person.
Major syndrome manifests as extrapyramidal symptoms of the head, face and neck, such as blepharospasm, clenching of the teeth, pouting, tongue protrusion and abnormal neck posture.
For patients who are candidates for surgery, deep brain electrical stimulation is used. During the surgery, stimulating electrodes are implanted in the skull to target the corresponding nerve nuclei in the brain. The surgery is more effective and safer.
Local injections of Botulinum toxin are also effective treatments for patients who are inoperable and cannot tolerate the side effects of the drug. The efficacy of the injections lasts for about two to three months, with subsequent repeated injections, which may have side effects such as causing facial paralysis and diplopia.
Some patients may also take oral medications. For example, antipsychotics such as clozapine, clonazepam, haloperidol; cholinergic receptor blockers such as phenazopyridine; dopamine receptor antagonists such as risperidone and olanzapine; and antiepileptic drugs such as carbamazepine and sodium valproate. However, these drugs may have side effects such as excessive sedation and postural hypotension.
It is recommended that patients go to the hospital to see a doctor to determine the best treatment based on their condition, and all medications should be used under the guidance of a doctor.