Fluconazole has some therapeutic effect on gray nails, but the cure rate is relatively low and there is less clinical information on the treatment of gray nails, so it is not currently used as a first-line treatment drug for gray nails. Fluconazole is a drug for the treatment of fungal infections, mainly for the treatment of candidiasis, which mostly occurs near the oral cavity, intestines and vagina, and needs to be used strictly in accordance with medical advice, because the side effects may cause gastrointestinal adverse reactions, manifesting as nausea, vomiting, abdominal pain or diarrhea, etc. It may also cause allergic reactions, manifesting as rashes and occasionally severe exfoliative dermatitis. Patients with serious underlying diseases, such as AIDS and cancer, may have abnormal kidney function and need to be used with caution. Currently, terbinafine and itraconazole are often recommended in clinical practice for the treatment of gray nails, and glacial acetic acid solution can also be chosen for topical treatment. In addition, ciclopirox and amorolfine can be used together, but these drugs should be used under the guidance of a dermatologist. In addition, nail extraction or removal of the diseased nail may be required in cases of distal nail plate involvement, macular streak nail, ingrown nail, or nail plate thickness >2mm. Laser and photodynamic therapy can also be used as an adjunct and alternative treatment for gray nails.