Babies infected with H. pylori are advised to seek prompt medical attention. Doctors will carefully consider the safety and benefit of eradication based on the baby’s infection and antibiotic use; when the benefit exceeds the risk, eradication of H. pylori can be implemented, with the dose of antibiotics adjusted according to the child’s body weight; if the benefit is lower than the risk, the treatment can be withheld for the time being. Compared with adults, children with H. pylori infection have a lower risk of serious disease, including peptic ulcer, atrophic gastritis, and gastric cancer, but there are more disadvantages to eradication. For example, there is a small choice of antibiotics and low tolerance to adverse drug reactions, and there is some spontaneous clearance of H. pylori infection in children, and the rate of reinfection after eradication is higher than that in adults, so our guidelines and expert consensus do not recommend routine H. pylori testing for children under 12 years of age. For children with peptic ulcer, endoscopy for dyspepsia, children with unexplained iron deficiency anemia, children searching for the cause of idiopathic thrombocytopenic purpura, and children with first-degree relatives who have gastric cancer, the benefit of H. pylori eradication outweighs the risk, and H. pylori testing and treatment can be performed according to the baby’s condition.