There is no scientific basis for the claim that toothpaste is used to kill and inhibit H. pylori. H. pylori infection is closely related to chronic gastritis, peptic ulcer and other diseases, which cannot be solved by brushing teeth. First of all, H. pylori mainly resides in the gastric sinus region, which requires harsh conditions for survival, even if there is H. pylori in the mouth, it cannot survive for a long time. And H. pylori is mainly spread through mouth-to-mouth transmission, stomach-to-mouth transmission and fecal-to-mouth transmission route, this toothpaste can not directly reach the gastric sinus region, and will not effectively block the spread of H. pylori, and can not effectively kill or prevent H. pylori infection. Secondly, the difference between toothpaste that claims to kill H. pylori and ordinary toothpaste lies mainly in the addition of lactoferrin, which is an important immune substance with antibacterial activity, but after all, it is not an antibiotic and cannot do the job of killing or inhibiting the effect of H. pylori. With the in-depth understanding of H. pylori, it is more important to strengthen the awareness of disease prevention in daily life, early and effective blocking of transmission routes, timely and correct detection and treatment.