Fever in leukemia patients after chemotherapy is mainly due to the decline in the body’s immune function and bacterial infection, which can be controlled by symptomatic treatment and medication. After chemotherapy, leukemia patients will lead to low levels of white blood cells, which will lead to a decline in the body’s immune function, thus increasing the possibility of infection with various pathogens such as bacteria, fungi, viruses, and fever symptoms. Symptomatic treatment of fever after chemotherapy for leukemia can be physical cooling, the use of anti-infective drugs, such as imipenem, meropenem and other medications, infection control will reduce the temperature, but also should pay attention to the patient’s surrounding environmental hygiene, to reduce the chance of pathogen contact. Leukemia patients with fever after chemotherapy, it is recommended to communicate with the competent physician in time to deal with. The above drugs need to be used under the guidance of a doctor to avoid self-medication.