There are no targeted drugs for pineal germ cell tumors, and they can usually be treated with radiation therapy and chemotherapy Germ cell tumors generally occur in the central system and are most common in the pineal region, where about 50% or more of germ cell tumors are found. Patients may experience symptoms such as inability to look upward with both eyes, dilated or unequal pupils on both sides, precocious puberty, and when the tumor is large, hydrocephalus and increased intracranial pressure may result. Generally, germ cell tumors are more sensitive to radiotherapy and chemotherapy, while surgery is usually performed to confirm the diagnosis by biopsy. There are currently no targeted drugs for pineal germ cell tumors, so patients are advised to consult their local hospitals and choose the appropriate treatment under their doctor’s guidance to control tumor growth and prolong their survival time.