The causes of renal cell carcinoma are not yet clear, which may be related to heredity, hypertension, obesity, occupational exposure and other factors. 1. Heredity: some patients with renal cell carcinoma have family genetic history, mostly inherited in autosomal dominant manner, which is caused by different genetic mutations. 2. Hypertension: Hypertension may be one of the factors of renal cell carcinoma, and some antihypertensive drugs can lead to increase the prevalence of renal cell carcinoma, such as thiazide diuretics. 3. Obesity: obesity may also be one of the factors for the development of renal cell carcinoma, which may be related to the increase of androgen and estrogen release by obesity, and may also be related to some cytokines released by fat cells. 4. Occupational exposure: Exposure to trichloroethylene, asbestos, polycyclic aromatic hydrocarbons and other substances in the occupational environment may increase the risk of renal cell carcinoma, such as workers in oil industry. Renal cell carcinoma may also be related to smoking and other factors. It is recommended that people with the above risk factors should have regular medical checkups and go to hospitals in time if they feel unwell, and follow the doctor’s instructions for treatment to avoid delaying the treatment.