Overview: Rheumatoid arthritis is a chronic systemic autoimmune disease with predominantly arthritic lesions. The main clinical manifestations are joint swelling and pain due to small synovial joints, followed by cartilage destruction and narrowing of the joint space, and in the late stage, severe bone destruction and resorption leading to joint stiffness, deformity and functional impairment. The prevalence of rheumatoid arthritis in China is 0.24-0.5%, with more women than men, about 2-3:1, and can develop at any age, with the greatest number of 20-50 year olds. The disease is mostly a recurrent disease with a high disability rate and poor prognosis, and there is no good cure. Clinical manifestations Morning stiffness, pain, pressure, swelling and limitation of movement in the affected joints, initially wandering and later fixed. It may vary from single to multiple joints. It is symmetrical. The small joints of the hands and feet are involved first, and the proximal interphalangeal joints, metacarpophalangeal joints and wrist joints are commonly involved. The most common deformities include proximal interphalangeal joint enlargement, claw-shaped hand, “swan neck” deformity of the fingers, ulnar deviation, metacarpophalangeal joint subluxation and wrist fixation. Tenosynovitis, bursitis, and muscle atrophy may occur around the joint. Subcutaneous nodules, mostly found in the joint prominence and often under pressure, are tough like rubber, no obvious pressure pain, and exist for a long time. 1, vasculitis. 2, chronic fibrous pneumonia. 3, diffuse interstitial lung fibrosis. 4, Nodular lung disease. 5, rheumatoid pneumoconiosis. 6, pleurisy. 7, rheumatoid granuloma of the heart. 8, focal myocarditis. 9, coronary arteritis. 10, chronic endocarditis and heart valve fibrosis. 11, rheumatoid pericarditis. Others: myositis, peripheral neuritis, sclerositis, etc. Diagnostic basis 1, morning stiffness for at least one hour (≥ 6 weeks). 2.Swelling of 3 or more joints (≥6 weeks) 3.Swelling of wrist, metacarpal, finger or proximal interphalangeal joints (≥6 weeks) 4.Symmetrical joint swelling (≥6 weeks). 5.There are typical radiological changes of rheumatoid arthritis in the hand. 6.Rheumatoid nodules under the skin. 7.Positive rheumatoid factor (titer > 1:32). Those who have more than 4 items can be diagnosed as typical rheumatoid arthritis. Treatment principles 1.Control the inflammation of joints and other tissues and relieve symptoms. 2.Maintain joint function and prevent deformity. 3.Repair damaged joints to reduce pain and restore function. 4.If conservative treatment is ineffective for 3 months and the synovitis cannot subside, synovectomy is required to protect the joint. 5.Surgery for joint deformity orthopedic surgery is feasible for patients with advanced stage. Medication principles 1.Oral non-steroidal anti-inflammatory and pain-relieving drugs, such as fenbendazole, fotarine, etc. 2.Immunosuppressants or chloroquine, rhodopsin tablets, etc. 3.Glucocorticoid. If necessary, use biological agents.