Nicorandil and isosorbide mononitrate should not be taken at the same time. Clinically, Nicorandil belongs to nitrate compounds, which can make intracellular calcium ions free to the outside of the cell, as well as dilate coronary artery blood vessels and increase coronary artery blood flow after taking it. It is mainly used in the treatment of coronary heart disease, angina pectoris and other diseases. Usually the drug may cause dizziness, headache, indigestion, palpitations (rapid heartbeat, often accompanied by panic) and other discomforts after taking it. It is contraindicated for those who are allergic to glaucoma, components of the drug. It is forbidden to use the drug when its properties change during the course of administration. Pregnant and lactating women need to use the drug under medical supervision. Isosorbide mononitrate belongs to the class of nitrate compounds, after taking it, it can relax vascular smooth muscle, dilate peripheral arteries and veins, so that coronary perfusion increases. It is mainly used in the long-term treatment of coronary heart disease and the preventive treatment of angina pectoris. Usually the drug may cause dizziness, fever, bradycardia and other discomforts after taking it. It is forbidden for people with acute circulatory failure, severe hypotension, glaucoma. In the process of taking the drug, it is necessary to pay attention to the monitoring of blood pressure and cardiac function and timely adjustment of medication, pregnant women and breastfeeding summarized above. Nicorandil and isosorbide mononitrate both belong to nitrate compounds. Taking them at the same time may lead to overdose and discomfort such as lower blood pressure, weak pulse and tachycardia. When taking the above drugs for treatment, it is recommended to decide on the dosage and learn the precautions to be taken after a comprehensive assessment of the condition by a doctor.