Thyroid nodules may not be cancerous when cystic solid nodular changes are present. Cystic solid nodules are relatively well differentiated, and when they form in the thyroid tissue, there may be protein and gelatinous material present, and there is a clear boundary between them and the surrounding thyroid tissue, and they are usually slow-growing, which is usually a sign of a benign lesion. When cystic solid thyroid nodules are detected, if the size of the lesion is relatively small, it can be reviewed regularly. If the localized nodule continues to increase in size and causes pain, difficulty in swallowing and other uncomfortable symptoms, it is best to have it removed surgically at the earliest possible time. Although cystic solid thyroid nodules are not a sign of cancer, there is a chance that they may become cancerous. Once cystic solid nodules appear, it is necessary to pay attention to a light diet, avoid overwork, and consult a doctor in time for examination and treatment. If cancer is found, surgery should be performed immediately.