Running has a certain effect on lowering blood lipids and blood sugar, but only if the movement is standardized and adhered to for a period of time. Running belongs to a kind of aerobic exercise, appropriate aerobic exercise can increase insulin sensitivity, especially for type 2 diabetes patients and pre-diabetes patients with obesity, exercise is one of the effective ways to control blood sugar. Moreover, long-term running can help reduce cholesterol, triglycerides and other substances in the blood, increase muscle content and consume fat tissue, which can help lower blood lipids and prevent diseases such as fatty liver and atherosclerosis. Therefore, running has a certain effect on lowering blood fat and blood sugar. However, it is necessary to adhere to a period of time and standardize the movement of each exercise. Patients with diabetes need to supplement appropriate calories before exercise to avoid hypoglycemia. Patients suffering from high blood sugar and high blood fat should actively cooperate with the doctor’s treatment, and they should exercise properly in their daily life.