High direct bilirubin, high indirect bilirubin and high total bilirubin are mostly considered to be caused by liver disease, biliary obstruction, hemolytic disease, etc., which can be lowered by general treatment, medication and surgery. 1. General treatment: patients should develop good habits of work and rest, ensure enough rest, avoid staying up late, overwork, etc., quit smoking and drinking, and strengthen the exercise appropriately. At the same time, pay attention to eat a light diet, maintain balanced nutrition. 2. Medication: If the patient is caused by viral hepatitis, he can take antiviral drugs such as acyclovir; if the patient is caused by cirrhosis, he can take drugs to protect liver cells such as silymarin and reduced glutathione. If it is caused by cholecystitis, antibiotic drugs such as aminobenzylpenicillin, clindamycin, or ursodeoxycholic acid can be used; if the patient is caused by hemolytic anemia, glucocorticoid drugs such as prednisolone and immunosuppressant drugs such as cyclophosphamide can be taken. 3. Surgical treatment: If the patient is caused by liver cancer, gallbladder stones, bile duct stones and other diseases, surgical treatment can be considered. If the patient has high direct bilirubin, high indirect bilirubin and high total bilirubin for a long time or repeatedly, it is recommended to consult a doctor in time to find out the cause and carry out targeted treatment. The medication should be taken in strict accordance with the doctor’s prescription, and should not be used on its own, so as not to delay or even aggravate the condition.