Determine renal tubular acidosis (RTA) based on patient history, clinical manifestations, laboratory tests, and other tests. 1. Patient history: Ask the patient about his/her medical history and whether he/she has had previous renal tubular disease. 2. Clinical manifestations: The main clinical manifestations of RTA are chronic hyperchloremic, metabolic acidosis, water and electrolyte disorders, such as hypokalemia or hyperkalemia, hyponatremia, hypercalcemia, hypokalemia, in addition to symptoms such as fatigue and nocturia. Children may show delayed fertility, and adults may show bone pain, bone deformity, bone softening or osteoporosis. 3. Laboratory tests: plasma PH value, urine biochemical tests, renal function tests, imaging tests and so on. It is recommended to consult a doctor in time when physical discomfort occurs, and make judgment under the guidance of a professional doctor.