High pepsinogen 1 may be at risk for diseases such as gastritis and peptic ulcer. 1. Gastritis: inflammatory reaction of the gastric mucosa caused by various reasons. The diet should be light and rest should be paid attention to. After improving the diet, the symptom relief is not obvious, can be given omeprazole acid suppression gastric protection, mosapride to promote gastrointestinal dynamics, if the combination of Helicobacter pylori infection, it is recommended that the eradication of Helicobacter pylori two antibiotics (Amoxicillin, Clarithromycin) + Proton Pump Inhibitor (Omeprazole) + Bismuth (Bismuth Potassium Citrate)), which the selection of antibiotics should be under the guidance of the doctor to use the drug. 2. Peptic ulcer: Inflammatory reaction, necrosis and detachment of the mucosa of the digestive tract due to various reasons, forming an ulcer with deep lesions. Diet should be light, quit smoking and alcohol, avoid taking drugs that stimulate the mucosa of the digestive tract (aspirin, sodium aceclofenac)d and other drugs. Do need to take, it is recommended to use drugs under the guidance of a doctor, can be given omeprazole acid suppression, Rebapatide to protect the gastrointestinal mucosa. When pepsinogen 1 is high, it is recommended to go to the hospital in time, after clarifying the cause of the disease, targeted treatment, to prevent the delay of self-medication, especially the elderly. Drugs should be used in accordance with medical advice.