One day, her mother came into the clinic with her labs. She came to see us for pain in the small joints of her hands, and my first feeling was that it was like rheumatoid. There were too many patients at that time, so I briefly explained to her, ordered labs, checked rheumatoid factor, blood sedimentation and anti-CCP antibody, and asked her to come for follow-up next week. Today, she came to the follow-up appointment with the labs. As I expected, her rheumatoid factor was 315, her anti-CCP antibody was 216, and her blood sedimentation was 34, which is the active stage of rheumatoid arthritis. I was about to prescribe her medication when she suddenly said to me, “Doctor, please tell me, do I have an undead cancer – rheumatoid? You have to help me, I just graduated from college. I suddenly noticed that her face was very ugly and the circles under her eyes were dark. Her mother told me that since she came home from the last clinic, she was always reading rheumatoid arthritis information on the Internet, looking at the deformed joints on the Internet, thinking about the future of her disease, and could not sleep overnight. I immediately told her that rheumatoid is not an immortal cancer, after so many years of efforts of rheumatologists around the world, the level of rheumatoid treatment has improved a lot, as long as active treatment, standardized medication, most of them can be controlled well, just like a normal person’s life. This time, I spent nearly 20 minutes telling her about this, and after prescribing the medicine, I carefully told her to use the medicine and come to our hospital once a month for a review. As time went by, the symptoms became less and less severe, and the joint pain improved significantly and went into remission. A year later, after we did a review and adjusted the medication, she gave birth to a healthy and lively baby, and I was as happy as she was when she walked into the department with her baby in her arms. I would like to tell all rheumatoid arthritis patients here that rheumatoid is not an undead cancer. Although it is not as fast as a cold, it is not like a cancer that can make you lose confidence. Many years ago, rheumatoid arthritis was a very difficult disease to treat, and medical doctors have made continuous efforts. Many years ago, American Indians knew how to use tea made of willow bark to reduce fever, and some people in Rome used poplar bark to treat sciatica. Why do “willow bark” and “poplar bark” have such a great power? This has been a mystery at the time. Later, scientists extracted salicylate from these plants and synthesized the basic chemical salicylate – pure salicylic acid, only to uncover the mystery of “willow bark” and “poplar bark This led to the creation of aspirin, a medicine that could reduce fever and relieve pain. The experimental specimen of aspirin in its pure state was invented by German chemist Felix Hoffmann. After its invention, aspirin was quickly recognized by the medical community. The great Russian writer and physician Anton Pavlovich Chekhov used aspirin to treat his own colds, rheumatic pains and arthritis, while some doctors in other European countries used aspirin to treat migraines. Prednisone was first used to treat rheumatoid arthritis in 1948, and Kendall, Reichstein, and Hench were awarded the Nobel Prize in Medicine for their outstanding contributions in this area. Studies have shown that prednisone has effects on both immunomodulatory proteins and immunomodulatory cells, including reducing exudation, decreasing the production and action of inflammatory mediators, and reducing the aggregation and activation of inflammatory cells. Undoubtedly, prednisone has indeed demonstrated an unparalleled ability to improve RA in our clinical practice. Antipyretic and analgesic drugs represented by aspirin and prednisone dominated the treatment of rheumatoid arthritis for a long period of time. Since these drugs only relieved symptoms, did not improve the disease and slowed its progression, many patients relied on them to relieve their pain, but the joints remained deformed and eventually became incapacitated, or even died due to complications. In this period of time, rheumatoid got the name of the undead cancer. However, medical doctors have never stopped researching the control of rheumatoid conditions. Methotrexate (MTX) was first synthesized by Seeger in the 1940s and was initially used to treat tumors. The drug has also been used in rheumatic diseases for 50 years now, and although the mechanism by which methotrexate is used to treat RA is not fully understood, it is now generally considered to be the most effective DMARDs class of drugs, and its value in the treatment of RA is increasingly appreciated. In 1972, Hoffmeister was the first to report the effectiveness of low-dose methotrexate in the treatment of RA, and in a 15-year treatment follow-up of 78 patients, 45 patients (58%) achieved significant results, including 28 patients who achieved “complete remission” in 28 of these patients. Since then, clinical observation of methotrexate for RA was rapidly carried out in 1984 and 1985, and the results of four controlled studies were published one after another 25% of the patients in the treatment group showed significant improvement in joint swelling and pain, and the mean improvement in morning stiffness was 46%; the average decrease in blood sedimentation was 15%. Many scholars have compared the efficacy of methotrexate with other second-line drugs for RA and have not found any one drug superior to methotrexate in terms of symptom improvement or incidence of adverse effects, making methotrexate one of the most important drugs for the treatment of rheumatoid rheumatism. The basic therapeutic drug. In the late 1930s, Svartz first synthesized salazarin (5-aminosalicylic acid) and sulfasalazine by linking them through an azo bond, and reported the therapeutic response for rheumatoid polyarthritis and ulcerative colitis in 1942. The results of this clinical trial showed no significant difference in the effects of these three agents and within the next 30 years the results were widely accepted and research on the efficacy of salazosulfapyridine in rheumatic diseases was almost terminated. It was not until 1980 that McConkey reported encouraging results in 74 patients with rheumatoid arthritis treated with salazosulfapyridine: clinical symptoms improved significantly after 4 weeks, C-reactive protein and sedimentation decreased significantly, and symptoms remained in remission for more than 8 months. Many controlled clinical trials have since confirmed the therapeutic role of salazosulfapyridine in RA. Most of the drug reaches the colon after administration, where it is broken down by bacteria into sulfapyridine and mesalazine, the former of which may be active in rheumatism, and the latter of which is active in the treatment of ulcerative colitis Health Search. ingredients. Medical doctors continue to work on many drugs that are used clinically for the treatment of rheumatoid arthritis. There are also chloroquine, hydroxychloroquine, azathioprine, gold preparations, leflunomide and other slow-acting anti-rheumatic drugs continue to be used in the clinic, the combination of anti-rheumatic drugs program gradually standardized, so that many patients with rheumatoid arthritis improved, not only the joints are not painful, and can work and study normally, the chance of joint deformation has been much smaller, rheumatoid arthritis has long been not an undead cancer. In particular, the application of biological agents in the treatment of rheumatoid arthritis, let us once again see the light of day. Although biologics have not been applied to the clinic for a long time and their potential side effects remain to be further observed, the demonstrated efficacy is still encouraging. Of course, it is still necessary for doctors and patients to work well together to find the most suitable and economical and reliable combination treatment plan for patients. We must also not forget the remarkable contributions made by Chinese medicine practitioners to patients with rheumatoid arthritis. The first extant medical monograph in China, “Huangdi Neijing Suwen”, contains a special section on paralysis, indicating that paralysis was a common clinical condition at that time. The “Theory of Paralysis” provides a systematic and comprehensive discussion of the causes, pathogenesis, classification and clinical manifestations of paralysis. In the Han dynasty, Zhang Zhongjing’s “Golden Plaque Essentials” proposed the following: “wind-dampness”, “calendar joints”, “blood paralysis”, “kidney paralysis”, and “fox confusion”. “These diseases, although they have their own characteristics in terms of etiology and clinical manifestations, all belong to the category of paralysis. These diseases are similar to rheumatoid arthritis, rheumatism and rheumatoid arthritis, fox confusion and leukoarthrosis, and yin-yang toxicity and systemic lupus erythematosus. Zhang Zhongjing has proposed different treatments and prescriptions for different diseases and different symptoms. For the treatment of episodes of disease, Gui Zhi and Peony Zhi Mu Tang and Wu Tou Tang are used. For the treatment of blood paralysis, there is Huangmao Gui Zhi Wu Wu Wu Tang, and for the treatment of kidney problems, there is Gan Jiang Quan Zhi Tang. For the treatment of fox confusion, there are Glycyrrhiza glabra diarrhea Heart Soup, Bitter Ginseng Soup and Radix Angelicae Sinensis. For the treatment of yin and yang toxicity, there is Shengma and Turtle Nail Soup. Zhang Zhongjing’s contribution to rheumatism in Chinese medicine was to apply the thinking of discriminatory treatment to the treatment of paralysis, and the formulas he created are still effective today and are widely used in clinical practice. The treatise “Treatise on the Origin of Diseases”, written by Chao Yuanfang in the Sui Dynasty, is a monograph on the symptoms of paralysis. “The book enriches the clinical manifestations of various paralysis diseases. The descriptions of “rheumatism, or skin thickening, or muscle pain” are similar to those of scleroderma and dermatomyositis in Western medicine. Since then, the four great masters of Jin-Yuan (Liu Wansu, Zhang Congzheng, Li Dongyuan, and Zhu Zhenheng), as well as warm disease scholars (Ye Gui, Xue Xue, Wu Xue, and Wang Mengying), and Wang Qingren and other physicians have offered their own opinions on paralysis. It can be said that the famous Chinese medicine practitioners who have appeared in all dynasties since the Nei Jing have their own academic thoughts on paralysis. Even today, with the emergence of arguably advanced drugs like biologics in the treatment of rheumatoid arthritis, these academic ideas are still a rich treasure, and we can still draw on these valuable academic achievements to improve the symptoms of patients and alleviate their suffering. Suffering from rheumatoid arthritis is undoubtedly painful, but on the basis of modern medicine and with the accumulation of many years of motherland medicine, they are happy again compared to the rheumatoid patients in the past. Because, rheumatoid long ago is not an immortal cancer, but only a controllable, but may be a disease that requires long-term treatment, just like hypertension, diabetes, these diseases, as long as long-term, standardized treatment, completely normal and happy life.