Chronic atrophic gastritis type O1 refers to moderate atrophic gastritis, and the main treatment includes general treatment and drug treatment. 1. General treatment: patients are advised to develop good dietary habits, eat regularly, quit smoking and drinking, eat a light, easily digestible diet, avoid increasing the burden on the stomach, and try not to ingest drugs that stimulate the gastric mucosa. 2. Drug therapy: chronic atrophic gastritis easily caused by H. pylori infection requires the eradication of H. pylori with 1 proton pump inhibitor (e.g., omeprazole) + 2 antibiotics (e.g., clarithromycin, amoxicillin) + 1 bismuth (e.g., fucus bismuth). Gastric mucosal protectants, such as magnesium aluminum carbonate; gastrointestinal stimulants, such as mosapride; anti-anxiety and depression drugs, such as sertraline, can also be applied according to the condition. The above drugs should be used under the guidance of professional physicians. Patients with chronic atrophic gastritis type O1 are advised to consult a doctor in time and standardize the treatment under the doctor’s guidance to avoid delaying the condition.