Cholinergic urticaria generally has no genetic predisposition and should be avoided mainly by avoiding external stimuli and local stimuli in life. 1. Cholinergic urticaria belongs to one of the types of urticaria, usually characterized by small and itchy dot-like masses. There is no genetic predisposition, and it is more common in young people with allergic body, and less common in the elderly. 2. Excessive exercise, stress, alcohol consumption, eating hot drinks, hot baths, hot weather, wearing tight clothing or emotional stress, etc., will increase the local center of the skin temperature, prompting the cholinergic nerve impulses and the release of acetylcholine, which in turn acts on the mast cells, thus triggering the disease. The above triggering factors should be avoided as much as possible to avoid the emergence and recurrence of cholinergic urticaria. It is recommended that patients with cholinergic urticaria go to the hospital in time, cooperate with the doctor to eliminate the triggers and symptomatic treatment, and follow the doctor’s instructions for medication.