Thyroid nodule grade 3, generally referred to as TI-RADS grade 3, suggests that it may be benign and the malignant rate of the nodule is less than 2%. Conservative treatment, medication, and surgical treatment can be chosen according to the condition, and most of the grade 3 nodules are benign and have mild symptoms, and regular review is sufficient. The TI-RADS classification of thyroid nodules is mainly based on nodule morphology, echogenicity, blood supply, calcification and other related factors to assess the benign or malignant nature of the nodules. the malignancy rate of nodules with TI-RADS classification of grade 3 is less than 2%, which is likely to be benign. They are usually benign such as thyroid cysts, high-functioning adenomas, and nodular goiters, but there is also no more than a 2% chance that the nodule is malignant. If it is accompanied by hyperthyroidism, it can be treated with antithyroid drugs such as methimazole; if it is accompanied by hypothyroidism, it can be treated with drugs such as levothyroxine tablets; asymptomatic patients can be followed up regularly. If the nodule is too large and produces obvious pressure or pain symptoms, surgical resection is feasible. It is recommended that patients should consult the doctor in time to choose the appropriate treatment plan.