It is possible for the nodules to become larger during hyperthyroidism treatment, which is related to factors such as improper treatment and malignant changes in the nodules, but not all hyperthyroidism treatments result in larger nodules. Hyperthyroidism is mainly characterized by overproduction of thyroid hormones, and treatment mainly includes antithyroid drugs, radioactive iodine and surgery. In the absence of stabilization of hyperthyroidism, enlarged thyroid nodules may occur. It is also necessary to clarify the nature of the thyroid nodules, including thyroid ultrasound and thyroid tissue biopsy. Benign nodules are just recommended to be reviewed regularly, while malignant or suspected malignant nodules are recommended to be surgically removed. During the treatment of hyperthyroidism, it is also necessary to control the diet, eat less iodine-containing foods, such as marine fish, kelp, nori, etc., quit smoking and limit alcohol, and ensure sufficient rest so as not to affect the treatment of hyperthyroidism. Any abnormality during the treatment of hyperthyroidism should consult a doctor in time and have a regular review.