The hand with fistula in uremia is usually the limb on the side of the forearm after endovascular fistuloplasty in patients with uremia. The causes of its sudden pain are local puncture abnormality, blood-stealing syndrome, swollen hand syndrome, internal fistula thrombosis and other etiologies. 1. Local puncture abnormality: as uremic patients with forearm endocardial fistula need to be punctured to maintain hemodialysis, its puncture operation is inappropriate or local compression is not complete, can be sudden pain in the hand, accompanied by blood seepage and other symptoms. 2. Stolen blood syndrome: uremia do fistula hand cold, weakness, swelling, severe hand pain and numbness, check the dorsum of the hand edema and dryness, etc., clinically can be manifested as a sudden pain in the hand. 3. Swollen hand syndrome: due to venous return obstruction or arterial blood pressure, resulting in venous return obstruction in the distal limb, so the hand pain, swelling and other manifestations. 4. endocardial fistula thrombosis: if the patient has low blood pressure, diarrhea, endocardial fistula side of the limb after exertion and other conditions suddenly appeared hand pain, can not rule out the possibility of endocardial fistula thrombosis, at this time need to pay attention to observe whether to hear and endocardial fistula murmur and palpation and tremor. Uremic patients with forearm endovascular fistuloplasty hand sudden pain there are many causes, it is recommended to timely regular hospitals, under the guidance of physicians to clarify the causes and treatment options, to avoid their own blind use of drugs.