Currently, bio-complementary tablets are not used much in clinical practice due to their characteristics and price. However, in some cases, biopatches are indeed more suitable than synthetic patches and may even be a better choice for certain clinical situations. Biological patches are most commonly used clinically in young men who have not had children and in young to middle-aged men with inguinal hernias who have fertility requirements, mainly due to the inconclusive effect of synthetic patches on fertility. The inguinal hernia occurs in the area where the male spermatic cord passes through, which contains the vas deferens and the arterioles supplying the testes that are closely related to fertility, and if the structure of the spermatic cord is severely affected by the procedure and the material, it is possible to cause infertility. The synthetic patch is a lifelong foreign body, and when placed in the body it stimulates the body to develop chronic and acute inflammatory responses, which the body uses to form a scar-like fibrous connective tissue locally to form a strong barrier. However, there are two sides to the coin: the foreign body reaction, which makes the synthetic patch a good repair, may also affect the spermatic cord immediately adjacent to the patch. In animal studies, some animals were found to have adhesions of the spermatic cord after implantation of the patch, and some animals even had vas deferens obstruction. Whether such foreign body reactions in humans lead to infertility on the surgical side cannot be resolved by animal testing, and there are indeed case reports of similar animal testing. However, for the population as a whole, the studies we have done can only compare infertility rates in people of the same age, and the differences are not significant in terms of the data. However, neither researchers nor doctors can conclude that synthetic supplements definitely have no effect on fertility. The characteristics of the current bio-complement are that it is not a lifelong foreign body, and that inflammation and foreign body reactions after implantation will be reduced in a relatively short time and disappear with its own degradation. Therefore, the bio-complement itself should have no effect on fertility, so using a bio-complement for male patients with fertility requirements is an option to avoid adverse effects on fertility. Of course, as mentioned earlier, patients may face an increased rate of future recurrence. The second scenario for bio-complement use is when there is local infection or contamination of the surgical repair. We know that synthetic patch is a lifelong foreign body, once infection occurs, it is difficult to control the infection completely due to the persistence of the foreign body, and if the infection cannot be controlled, the only way to remove the synthetic patch that has become a pure foreign body is through another surgery, which means not only the complete failure of the first repair surgery, but also the second surgical blow to the patient. This is the biggest weakness of synthetic patches, and all kinds of international and national surgical guidelines state that synthetic patches are not recommended in cases of infection and heavy contamination. At this point, biopatch, which is highly resistant to infection, becomes the only option in such clinical situations. Even if the infection is so severe that the patch itself cannot be fully repaired, the patch itself will eventually degrade without the need for re-surgical removal, which is still very beneficial to the patient’s prognostic outcome. Another indication for the use of biopatch is the reconstruction of the abdominal wall after resection of abdominal wall tumors in patients with abdominal wall tumors, which can avoid the local management difficulties caused by tumor recurrence in the location of the synthetic patch, as in the case of synthetic patches, which is not in the field of hernia and will not be described in detail here. Therefore, biological patches are still very useful in clinical practice. At the same time, with the development of material science, through the search for new materials and the improvement of current materials, it is still possible to develop new patches in the future to overcome the shortcomings of current biological patches. At that time, the application of biopatch will be more extensive, and it is indeed possible to completely replace synthetic patches.