Biting pepper can relieve toothache, which is a folk remedy, because pepper contains anesthetic ingredients, so biting pepper can relieve toothache to a certain extent, but this does not exist a clear scientific basis, and in clinical practice is not recommended to use such folk remedies to treat toothache. Patients with toothache can take their own pain medication at home to relieve the pain, such as oral ibuprofen (fen-phen) and other drugs to relieve the pain. In addition, it is important to seek medical attention to find out the specific dental disorder and treat it in order to solve the root of the pain problem. The most common type of toothache is caused by pulpitis or periapical inflammation, which requires root canal treatment to remove the infected pulp nerve to completely stop the pain. If the pain is caused by periodontitis, systematic periodontal treatment is required. If the pain is caused by pericoronitis of the wisdom tooth, an adequate amount of anti-inflammatory antibiotics is required.