Multiple bilateral breast nodules should be judged in the light of the patient’s clinical manifestations and the results of ancillary tests, including observation and the administration of surgery, drugs, chemotherapy and radiotherapy. Women presenting with bilateral breast multiple nodules, if there is no clinical manifestation in the nodules, relevant examinations such as ultrasound, molybdenum target, etc., need to be carried out, and the treatment will be decided according to the results. If the nodules have clinical manifestations. If the clinical manifestations are mainly pain, and the pain occurs at the same time with the menstrual cycle, it is most likely to be breast hyperplasia, according to the clinician’s judgment to decide whether to take medication such as Prosperity powder, tamoxifen and so on. If the breast nodule is accompanied by nipple discharge, bleeding, skin indentation on the surface of the breast, breast skin edema and so on. Combined with an ultrasound classification of category 4 and above, treatment is most often required. Specific treatments should be adequately assessed for the patient’s condition. These include surgery, radiotherapy, and medications such as trastuzumab, tamoxifen, docetaxel, paclitaxel, and others. Patients with multiple nodules in both breasts should be seen promptly and treated aggressively.