Skull defects are very common in current clinical practice, either because of accidents or because they are left over from brain surgery. Skull defect is not a small problem, and the skull itself plays a protective role for the brain, once the defect occurs the protective barrier is broken, then a series of dangers may occur. Firstly, the skull shape will be changed after skull defect, so the patient will lose self-confidence and become very inferior after a long time; secondly, it will cause skull defect syndrome, the patient will often feel headache and dizziness, memory is obviously not as good as before, also insomnia and become unresponsive; thirdly, after skull defect, the intracranial tissues are easily attacked by the outside world, and if a secondary collision occurs, the consequences are even more unimaginable. Cranial defect can not be sloppy, it is recommended that patients go to the hospital to do cranial repair surgery in time, which is a routine surgery with small risk and mature technology. However, skull repair surgery has to focus on the choice of materials, the material is good or bad is directly affect the post-operative recovery and effect; at the same time to carefully select the surgical experts, the doctor’s technical experience is very important. Currently, titanium alloy material is widely used, it is a certain progress than those early materials, but does skull repair titanium alloy have any effect on the future? Indeed, there are some problems after titanium alloy repair cranial bone surgery, such as easy infection and rejection reaction, postoperative patient’s sensitivity to external hot and cold environment, and also affect the postoperative medical examination. On the issue of skull repair, we use a new type of polyether ether ketone peek material, which has more advantages than titanium alloy, and all the properties are very close to the autologous skull, in addition, we also continuously carry out technical improvement and upgrade and material optimization design, and also introduce the concept of aesthetic plastic surgery, and carry out peek skull repair plastic surgery, which can achieve the organic unity of structural recovery, functional perfection and beautiful appearance. The organic unity of structural restoration, functional perfection and aesthetic appearance can be achieved.