The generic name of Nexium is esomeprazole magnesium enteric-coated tablets, and prolonged use of esomeprazole magnesium enteric-coated tablets can cause atrophic gastritis. Esomeprazole magnesium enteric-coated tablets belong to the proton pump inhibitors and are used in the treatment of gastritis, reflux esophagitis, eradication of Helicobacter pylori, and peptic ulcer. It is contraindicated for those who are allergic to this product. Adverse reactions such as headache, diarrhea, abdominal pain, fatigue, chest pain, tinnitus, anemia, etc. may occur during the administration of this product, and some studies have shown that atrophic gastritis was occasionally found in gastric pathology biopsy of patients who have been taking esomeprazole magnesium enteric-coated tablets for a long period of time. So prolonged administration of this product may cause atrophic gastritis. However, the incidence is low and the time at which atrophic gastritis will develop after administration is not clear. Adverse drug reactions are inevitable, the doctor will make targeted, individualized treatment plan according to the patient’s condition, so patients do not have to have too much psychological burden, need to follow the doctor’s instructions to take the drug to avoid adverse effects.