Trigeminal neuralgia is a common neurological disease of the brain, mainly based on recurrent paroxysmal pain in the distribution area of the trigeminal nerve, each onset of pain is like a knife cut, burning unbearable, clinical treatment, many doctors will prescribe drugs such as carbamazepine to relieve pain through pain relief, but it is difficult to eradicate the disease. Can drugs cure trigeminal neuralgia? Many patients are treated with oral medications such as carbamazepine and phenytoin sodium at the early stage of trigeminal nerve onset. The main purpose of carbamazepine and phenytoin sodium for trigeminal neuralgia is “analgesia”, which fundamentally will not cure trigeminal neuralgia completely. In addition, during the process of taking medication, the patient’s condition is repeatedly good and bad, and the distress of the disease can easily cause serious adverse psychological effects on them, especially some patients with serious conditions have lost confidence in treatment and life because they have been suffering from pain for a long time. Of course, it is not that medication for trigeminal neuralgia is a wrong way of treatment. For example, although carbamazepine and phenytoin sodium cannot fundamentally cure trigeminal neuralgia, their “analgesic” effect can help patients temporarily relieve the pain and improve their quality of life. In addition, some patients also take “herbal therapy” in the treatment, although its therapeutic effect is not as obvious as surgery, but also has a certain effect, which is still very helpful to the treatment of the condition. We should have a scientific and dialectical understanding of medication for trigeminal neuralgia, and we should not completely deny the therapeutic effect of medication, nor should we put the cure of the disease on medication. Microvascular decompression is the standard treatment for trigeminal neuralgia in the world, and it is the only surgery that can cure trigeminal neuralgia at present. Under general anesthesia, a 4-cm longitudinal incision is made behind the affected ear, inside the hairline, and a cranial opening of about 2 cm in diameter is made to access the pontocerebellar angle under a microscope. Once the responsible vessels are isolated, the source of irritation disappears and the hyperexcitability of the trigeminal nucleus disappears and returns to normal. Immediately after surgery, the patient’s pain disappears and normal facial sensation and function are preserved without affecting the quality of life. After microvascular decompression for trigeminal neuralgia, the anatomy of the trigeminal nerve can be preserved intact, and the normal neurological function of the trigeminal nerve can be preserved. Some patients can also eliminate the state of hypertension caused by vascular compression of the brainstem and achieve the purpose of radical treatment of hypertension. Because microvascular decompression has the advantages of obvious pain relief, non-destructive, little side injury, and very low recurrence rate, it is currently the safest and most effective method applied in the treatment of trigeminal neuralgia internationally.