Indications: 1. Botulinum toxin (Botox) has the best effect in treating the upper 1/3 of facial wrinkles, such as: forehead lines, frown lines, crow’s feet, wrinkles on the back of the nose, etc. It is suitable for those who are reluctant to undergo surgery, those who have concerns about surgery, and those who are not suitable for surgery. 2, thin face, thin legs: for the facial bite muscle hypertrophy, calf muscle developed, can achieve the effect of making the face thin, calf thinning. 3, local hyperhidrosis: axillary, palms, soles of the feet of hyperhidrosis. 4, axillary hyperhidrosis: that is, axillary odor or fox odor. Contraindications: 1, people with severe muscle weakness. 2, neuromuscular disease. 3, allergic constitution. 4, pregnancy and lactation. 5, within two weeks of taking aspirin or other antipyretic and analgesic drugs. 6.Users of aminoglycoside antibiotics (such as gentamicin, streptomycin, etc.). 7.People who are mentally abnormal and have poor self-control. 8.Patients with serious heart, liver, kidney and lung diseases or connective tissue diseases.