Diabetes can cause abnormal liver and kidney function due to multiple organ damage or prolonged use of medication. Therefore, it should be timely and effective treatment, of course, because of poor liver and kidney function, so it is necessary to pay attention to the choice of drugs, should be as far as possible to choose a small impact on the liver and kidneys of the drug is appropriate. In general, if diabetes combined with hepatic insufficiency: insulin is preferred; secondly, alpha-glucosidase inhibitors, such as acarbose or voglibose, can be considered; GLP-1 agonists are optional in mild hepatic insufficiency; other hypoglycemic drugs are used with caution in hepatic insufficiency; for diabetes combined with renal insufficiency: Repaglinide, nateglinide, rosiglitazone, and ligliptin can be used throughout conventional dose; while for other hypoglycemic drugs with GFR <60, they can be used in reduced doses according to discretion. However, it is still recommended to use insulin treatment. Of course, it can be adjusted with traditional Chinese medicine, commonly used Chinese medicine including urea clear granules, or with Bailing capsule, etc. You should also pay attention to the prevention of colds and flu, avoid straining, and ensure sufficient sleep to help improve the symptoms and prevent the aggravation of the disease, as well as pay attention to the regular review of kidney function.