HPV 52 positivity is a high-risk HPV infection. Most of these cases will turn negative on their own after about 8 months to 1 year, so it is recommended that in clinical cases where HPV 52 positivity is found, colposcopy should be done first to rule out whether the cervical mucosa has been lesioned by HPV infection. If no lesions have occurred, it is recommended to give regular follow-up examinations to see if the high-risk HPV infection has turned negative. If there is a lesion, laser treatment or microwave treatment can be done if it is a low grade lesion. In the case of high grade lesions, conical excision of the cervix is recommended and regular postoperative follow-up is recommended to see if the HPV has turned negative and if the cervical epithelium has become diseased again.