The Levantine test, a form of effusion testing, if positive, is considered to be an exudative effusion, most commonly due to inflammation. A negative Levantine test, on the other hand, is considered to be a leaky effusion, resulting from malignancy or anemia, as well as hypoproteinemia, and is used as a reference for clinical treatment. For pleural effusion, it is common to have tuberculous pleurisy, or intrapulmonary infection secondary to a positive Levantine test, and intravenous anti-infective therapy should be actively selected. For large pleural effusions, thoracentesis should also be performed under local anesthesia, and intermittent drainage of the fluid can alleviate the patient’s discomfort. For Levantine negative patients, intravenous supplementation of human albumin or plasma, along with diuretics, can be used to gradually reduce discomfort and achieve clinical cure, if allowed.