The reason why the baby burps and spits out a mouthful of milk may be caused by incorrect burping, overfeeding and other physiological reasons, but we can’t rule out necrotizing small bowel colitis, meningitis and other diseases. 1. Physiological reasons: If the burp is not correct, let the baby lie down immediately after the burp, there can be a burp and spit out a large mouthful of milk. In addition, due to the small capacity of the baby’s stomach, and in a horizontal position, if the one-time feeding too much milk, can lead to hiccups and spit up a large mouth of milk phenomenon. 2. Disease factors: (1) Necrotizing small bowel colitis: neonatal necrotizing small bowel colitis is a kind of gastrointestinal emergency that jeopardizes the life of newborns, especially premature babies. Children may vomit to varying degrees, usually milk first, which may be followed by bile or coffee-like material, accompanied by abdominal distension and gastric retention. (2) Meningitis: Due to the increase of intracranial pressure, children with meningitis may present with symptoms of vomiting, mostly projectile vomiting, mostly of milk or milk curd, accompanied by headache and impaired consciousness. In addition, in addition to the above diseases, pyloric spasm, congenital hypertrophic pyloric stenosis and other diseases can lead to babies burping and spitting up milk. Baby hiccups spit up a large mouth of milk, there may be other reasons, it is recommended to go to the hospital in time to improve the examination to clarify the cause of the disease, to give targeted treatment or treatment.