On the one hand, the decomposition of urea destroys the weak acidic environment as a natural barrier, making it easy for other pathogenic microorganisms to colonize and infect, which is not conducive to sperm survival and can cause necrosis of mucosal cells and stagnation of tubal cilia movement; on the other hand, the increase in hormone levels during pregnancy increases the toxicity of mycoplasma, induces immune damage, destroys the mother’s autoimmune tolerance mechanism, and damages the endometrium. The endometrium metabolism and physiological functions, interference and destruction of embryonic development, and ultimately promote tissue embryo loss, resulting in miscarriage and infertility. 2, the original infection after a variety of specific antigens, antibodies have a negative impact on pregnancy. Some scholars have reported that UU infection and repeated UU infection can activate a variety of inflammatory cells to secrete interleukins (
IL-1, IL-2, IL-6, etc.), INF and cytokines such as TNF and NK cells, which disrupt the normal cellular metabolism and lead to infertility. Other studies have shown that UU infection leads to elevated local anti-sperm antibodies (AsAb), anti-endometrial antibodies (EmAb) and anti-cardiolipin antibodies (ACA) in the reproductive tract, and interferes with sperm-egg binding, conception and implantation through cellular conditioning and complement-mediated. Mycoplasma sexualis and recurrent mycoplasma infections cause tubal inflammation and tubal scar formation, which ultimately affects tubal motility and patency, leading to tubal infertility (TFI). These mechanisms can act individually or in combination to cause female infertility. 4, according to clinical research shows that mycoplasma infection positive group of pregnant women, the occurrence of preterm delivery, fetal distress, neonatal asphyxia rate is significantly higher than the negative, a variety of mycoplasma co-infection than a single mycoplasma infection vertical transmission rate is higher than the rate of neonatal infection is significantly higher than a single mycoplasma infection, may be mycoplasma mixed host show a synergistic effect. Mycoplasma infection in pregnant women can be transmitted to the fetus and neonate by vertical transmission and have adverse effects on the course of pregnancy and the neonate. 5, with the widespread use of antibiotics, mycoplasma resistant strains are increasing, and the phenomenon of mycoplasma multi-drug resistance has emerged, and once mycoplasma resistance appears, it may be a multi-drug resistant strain, especially Uu + Mh mixed infections. Therefore, the clinical patients with symptoms should be determined according to the results of mycoplasma culture to determine whether there is a mixed infection, and then select drug therapy to avoid abuse, in order to improve the efficacy and cure rate.