The quantification of hepatitis B virus DNA is less than 20 IU/ml, which indicates that the current testing reagents cannot detect the replication of hepatitis B virus and can be said to be negative for hepatitis B DNA. If the patient is negative for hepatitis B DNA during antiviral treatment, it means that the antiviral regimen has achieved relatively good results and the original antiviral regimen can be continued. If the patient has not undergone antiviral therapy, it means that the hepatitis B virus in the body is in a very low replication state. However, it should be noted that a negative hepatitis B DNA does not mean that there is no hepatitis B virus infection. If there is also a positive hepatitis B surface antigen, it indicates that the patient is still a hepatitis B carrier, but the amount of virus is extremely low; if there is also a negative hepatitis B surface antigen, it can be said that the patient is not a hepatitis B patient and does not have hepatitis B virus infection.