Supraclavicular lymph node enlargement is commonly caused by lymphadenitis, lymphoma and other malignant tumor metastasis, etc., which needs timely medical treatment for the cause of the disease, and the treatment methods include general treatment, medication, and surgical treatment. 1. Lymphadenitis: it is mostly caused by infections in the upper limbs, face, neck and shoulder, such as streptococcus haemolyticus or staphylococcus aureus, etc., which cause enlarged lymph nodes and pain, and it can be treated with ceftriaxone sodium, roxithromycin and other medicines for anti-infective treatment. In daily life, pay attention to rest, strengthen physical fitness, quit smoking and alcohol. 2. Lymphoma: it can also cause enlarged lymph nodes, need to be punctured to confirm the diagnosis, after diagnosis, can be operated with radiotherapy (such as vincristine, etc.), immunotherapy (such as interferon, etc.), bone marrow transplantation and other treatments. 3. Malignant tumors: malignant tumors such as stomach cancer can be transferred to the right supraclavicular lymph node through lymph nodes, resulting in enlargement. One should consult doctor in time and confirm the diagnosis by puncture. After being identified as tumor, if there is a chance of surgery, it should be actively treated by surgery; it can also be combined with radiotherapy and targeted therapy. The applied drugs include Sorafenib, Erlotinib, etc. Supraclavicular lymph node enlargement has various conditions, inflammation and tumor may occur, therefore, once found, should consult the doctor in time, after clarifying the cause of the disease, under the guidance of the doctor to standardize the treatment.