Monkeypox is a rare zoonotic infectious disease that can be transmitted through contact with body fluids, blood and droplets of monkeypox virus infected patients. 1. Transmission through body fluids: contact with exudate from broken mucous membrane, cerebrospinal fluid, lymphatic fluid, semen and vaginal fluid of patients infected with monkeypox virus. 2. Blood transmission: contact with infected person’s blood-contaminated items such as syringes, infusion sets, scalpels and blood-contaminated clothes and supplies. 3. Droplet transmission: When you are in close contact with a monkeypox patient without wearing a mask or other protective equipment, you can spread the disease through respiratory droplets face to face. So in order to avoid monkeypox virus infection, you need to do a good job of their own protection, keep a distance from the diagnosed patients, cut off the transmission pathway, can better inhibit the infection.