What painkillers to take for pancreatic cancer need to be selected according to the degree of pain, as follows: 1. If the pain is mild, you can take some painkillers with general pain relief effect, such as non-steroidal antipyretic and analgesic drugs like aspirin and ibuprofen. 2. 2, if the pain is moderate, you can eat some weak opioid drugs, such as tramadol extended-release tablets. 3, if the pain is severe, you need to eat the best pain relief effect of strong opioid pain medication such as morphine sulfate tablets, oxycodone hydrochloride extended-release tablets, etc.. These pain medications can be taken orally as much as possible, the oral side effects are minimal, and the pain relief time is also longer. They need to be taken orally on time, and even if there is no pain after the time, they need to be taken orally, so that the efficacy is the best, and they are not easily addictive. If the patient’s health condition can be treated with anti-tumor therapy, it is still necessary to carry out anti-tumor therapy. After the tumor shrinks, the pain will naturally be reduced.