Recently, a 55-year-old patient with severe multi-segmental lumbar disc herniation was cured in our department. The patient was discharged after 10 days of hospitalization, which became another milestone in minimally invasive treatment of lumbar multi-segmental disc herniation in our department. The patient had been suffering from lumbar pain and leg pain for more than 5 years, mainly lumbar pain, and in the past 6 months, he had severe cramps in his left leg, often waking up with cramps at night, and pain in his right leg with plantar numbness, and he could not move his back for 5 days. After patient consultation and detailed examination, the patient was finally diagnosed with lumbar disc herniation in combination with CT results. The patient was characterized by severe disc herniation in all three segments, severe symptoms, and multiple symptoms such as numbness and muscle atrophy due to spinal cord injury. The open surgery required internal fixation frame and was significantly more complicated and dangerous than the single-segment disc herniation surgery, and the patient’s fear of surgery led to a strong request for CT-guided minimally invasive intervention to relieve the compression of the herniated material. A detailed and thorough treatment plan was developed after multiple considerations. First of all, the intravertebral environment was reasonably regulated and treated with intravenous assisted infusion, which significantly eliminated the patient’s pain in three days and enhanced the patient’s self-confidence in treatment. Three days later, the patient underwent minimally invasive lumbar intervention (radiofrequency therapy with collagenase chemonucleolysis), and the procedure went smoothly. Ten days later, the patient was discharged from the hospital with high praise and deep gratitude to all the medical staff of the pain department. This minimally invasive technique has the advantages of small trauma, high safety, fast recovery and painlessness, and is accepted by more and more patients.