Normal people usually urinate 0-2 times at night, and the volume of urine is 300-400 ml, which is about 1/4-1/3 of the total 24 h. As we age, the ratio of daytime urine volume to nighttime urine volume gradually decreases, and the ratio is 1:1 by the age of 60. About is increased nocturia related to kidney disease? Nephrologists explain that if the number of urination and urine volume increase significantly at night, and the urine volume also exceeds half of the total urine volume throughout the day, it is called ‘nocturia’. Normal people generally do not drink and eat after dinner, and after sleep, the metabolic rate in the body is low and the blood flow is slow, so the original urine passing through the renal tubules can be fully reabsorbed, so the nocturnal urine is significantly less than the daytime urine volume. Nocturia is mainly caused clinically by: 1. mental factors leading to an increase in nocturia: mostly the number of nocturia increases, and the amount is generally not much. Strictly speaking, only the increase in the number of urination without an increase in the volume of urine does not belong to the category of nocturia. 2.Increased nocturnal urination by drainage: Due to water retention in the body, especially when cardiac insufficiency, the amount of cardiac blood return increases after lying down at night, and renal blood flow also increases, and the volume of urine also increases. It is common in patients with various heart diseases accompanied by cardiac insufficiency. 3, nephrotic nocturia increase: due to various reasons caused by kidney damage, so that renal function is reduced, the kidneys can not be completely excreted in the daytime metabolites in the body, need to continue to excrete at night, resulting in increased nocturia. It is common in patients with chronic renal insufficiency and so on.