Patients with hand, foot and mouth disease may develop rashes, herpes and ulcers on the hands, feet, mouth and buttocks, and in severe cases, drowsiness, irritability, shortness of breath, etc., which may even lead to death. Its treatment is through medication, symptomatic supportive therapy, etc., which should be formulated by the doctor according to the condition with a reasonable and effective program. Hand, foot and mouth disease is a common infectious disease in children caused by enterovirus infection. Typical clinical manifestations are rashes and ulcers on the skin and mucous membranes of the hands, feet, mouth, buttocks and other parts of the body, accompanied by systemic symptoms such as fever, malaise, etc., and the symptoms of most patients are mild. However, in a few patients, the disease progresses quickly, and symptoms of central nervous system damage such as drowsiness, easy to panic, headache, ataxia, etc., may also appear shortness of breath, cyanosis and other cardiopulmonary failure, which can lead to death in critical cases. Commonly used therapeutic drugs for HFMD include recombinant human interferon, ribavirin and other antiviral drugs. Patients with manifestations such as encephalomyelitis and persistent high fever may be given gammaglobulin as appropriate, and patients with decreased blood pressure may be given vasoactive drugs such as dopamine and norepinephrine as appropriate. In addition, patients with fever can be given cold compresses and warm water baths, and treated with antipyretic and analgesic drugs such as ibuprofen and acetaminophen if necessary. For those with oral erosion, cod liver oil and watermelon cream can be applied. Hand, foot and mouth disease has a certain degree of contagiousness, it is recommended that patients appear hands, feet and other parts of the rash, should consult a doctor in a timely manner, and follow the doctor’s instructions to standardize the treatment.