The child said one ear pain in the middle of the night may be related to otitis externa, otitis media, foreign body blockage and other factors, according to the cause of the use of general treatment, drug treatment, specific analysis is as follows: 1. otitis externa: if the above situation occurs due to otitis externa, you may need to take antibiotics such as cephalosporin or amoxicillin for treatment, and also use levofloxacin ear drops with the use. 2. otitis media: otitis media can also cause one ear to hurt in the middle of the night, accompanied by hearing loss, fever and other adverse reactions, you can take oral cefaclor dry suspension or azithromycin and other drugs to treat, can effectively control the infection. 3. Foreign body blockage: some children have the above symptoms, may be due to the foreign body into the ear resulting in blockage, such as worms, toilet paper and so on. When the foreign body has not crossed the isthmus of the external auditory canal and is not embedded in the external auditory canal, it can be hooked out directly with a cerumen hook. When the foreign body is a movable insect, it is advisable to use oil, ethanol, etc. to drop into the ear first, and then remove it with forceps or rinse it out later. For hard spherical foreign bodies, such as glass balls and beads, which may be difficult to grasp, it is common to use a right-angled curved hook to pass over the foreign body or use a large pipette to suck the foreign body to remove it. If the foreign body is large, it is advisable to remove the foreign body under brief general anesthesia, so as to avoid injury or pushing the foreign body deeper into the ear due to uncooperative operation. Children’s ear pain in the middle of the night there may be other reasons, it is recommended to go to the hospital in a timely manner to carry out relevant examinations, after the cause of the disease is clear and active symptomatic treatment, in addition to the above drugs need to be taken under the guidance of a doctor, can not be used on their own.