There is no way to replenish the enzyme acetaldehyde dehydrogenase after it is missing. 1. Acetaldehyde dehydrogenase can oxidize ethanol to acetaldehyde, and then under the catalytic effect of acetaldehyde dehydrogenase, water and carbon dioxide will be produced and excreted from the body. If the body lacks acetaldehyde dehydrogenase, it is not able to expel ethanol from the body well, which can easily lead to drunkenness, mostly related to genetic factors, and can not be supplemented through external intervention. 2. Acetaldehyde dehydrogenase lack of people, usually try to drink less alcohol, if you drink alcohol after the appearance of obvious symptoms of intoxication, pay attention to drink more water or drink some sugar water, can promote urination, help excretion. In addition, the lack of acetaldehyde dehydrogenase, if a large number of people drink, it is easy to lead to alcohol poisoning, the emergence of uncomfortable symptoms, should promptly consult a doctor.