1, acute inflammation period can not be extracted, such as gum swelling and pain, biting pain and other acute symptoms are not suitable for tooth extraction, need to control the acute inflammation first, and then extract the tooth at a later date. First, the anesthesia effect is not good during the acute inflammation period, and it will be very painful to extract the tooth. Second, the operation of tooth extraction may lead to the spread of inflammation. 2. Women should not have tooth extraction during menstruation. Women’s blood clotting mechanism will change during menstruation, which increases the risk of bleeding after tooth extraction, and then there is menstruation, which decreases the body immunity and increases the risk of infection after tooth extraction. 3. Extraction is not suitable for those who have cold, fever, frequent cough, allergic rhinitis attack period and cannot breathe normally through the nasal cavity. 4. Patients with moderate or severe osteoporosis who have been using bisphosphonates for a long time, such as MIGUDA, cannot have their teeth extracted because this drug will not only affect the healing of the alveolar bone in the extraction wound but also cause severe pain. 5, hypertension, diabetes, hyperthyroidism, cardiovascular disease, long-term use of anticoagulant drugs, immunosuppressants, etc., need to inform the doctor in advance of the specific medication and control of these chronic diseases, so that the doctor can assess whether the tooth can be extracted. For cancer patients, if tooth extraction is required after radiotherapy, it is necessary to inform the doctor in advance of the detailed situation, as there is a risk of radioactive osteomyelitis after radiotherapy, not only is it difficult to heal the extraction wound, but also the extraction wound will be extremely painful and painful.