The basic principle of radiofrequency ablation is that the high-frequency oscillating current emitted by the electrode causes the ions around the electrode to vibrate in the direction of the current change, and the adjacent molecules hit each other and generate heat energy by friction; when heated to 45 ℃~50 ℃, the proteins in the tumor cells are denatured and coagulated necrosis occurs. When heated to 45 ℃~50 ℃, the protein in the tumor cell denatures and undergoes coagulative necrosis and DNA depolymerization; the tumor cell dies. The local temperature of the sub-electrode can reach 90 ℃, and the temperature of the middle part between the two sub-electrodes can reach 60 ℃, thus ensuring that the destruction area can reach 5 cm × 5 cm × 5 cm at one time. The local temperature of the sub-electrode can be 90 ℃, and the temperature of the middle part between the two sub-electrodes can be 60 ℃, thus ensuring the destruction area of 5 cm × 5 cm × 5 cm at one time, ensuring the inactivation of local tumor cells. The results of this group showed that the recent efficiency of radiofrequency ablation treatment was 9.75%, and the survival rates of 1, 2 and 3 years were satisfactory. It indicates that radiofrequency ablation therapy has the effect of improving the recent efficacy. However, there are still some patients with insignificant treatment effect, and the analysis may be due to the lesion tissue close to blood vessels, which reduces the ablation inactivation effect on local tissues because the rapid flow of blood takes away the heat generated by RF. In addition, the deviation of needle placement from the planned needle path causes the omission of tumor tissues, which is also the main reason to reduce the efficacy. If the tumor is close to the blood vessels or the tumor invades the lung hilum, it will cause incomplete ablation; the local heating of the electrode near the blood vessels is difficult due to the heat dissipation effect of blood flow, and the temperature of inactivation is not reached; the part near the lung hilum cannot be completely ablated, and the active tumor cells remain. Therefore, it is emphasized that patients should be selected far from the lung hilum and more than 1 cm away from large blood vessels. The best way to reduce the occurrence of pneumothorax is to improve the accuracy of puncture and reduce the number of needle insertions; intrapulmonary hemorrhage is mostly caused by vascular tracheal fistula through the pulmonary vessels and trachea, which should be decisively warmed up and coagulated, and the respiratory tract should be cleaned up in time; skin burns are mainly caused by the ablation time. The most serious complication is the rapid warming of the tissue around the sub-needle, and the withdrawal of the needle is wedge-shaped in the middle of the sub-needle, so that the sub-needle can not be recovered into the mother needle. Once the stagnant needle occurs, there is no need to panic. A small amount of saline can be injected from the lateral hole to dissolve and loosen the crust in front of the needle, and then the needle can be pulled out, but do not forcefully and violently pull out. The treatment result of lung cancer radiofrequency ablation largely depends on the accuracy of puncture needle, which is also one of the difficulties in this work; fast and accurate needle entry can also greatly reduce the occurrence of complications. For the positioning of single-point ablation, we adopt the sequential needle insertion of biopsy needle and ablation needle; for multi-point ablation, we adopt the multi-stitch ablation method with more than two stitches, so as to ensure the accuracy of needle insertion and minimize the number of punctures. The medium and long-term effects of radiofrequency ablation in the treatment of advanced non-small cell lung cancer have not been reported at home and abroad. We found that the median survival time, 1-year survival rate, 2-year survival rate, and 3-year survival rate of cases treated with radiofrequency ablation were satisfactory; due to the short follow-up period, the 5-year survival rate has not yet been calculated, and the more long-term efficacy Further observation is needed. The question of how to combine radiofrequency therapy with chemotherapy and local radiotherapy to improve the efficacy, we believe that the comprehensive treatment of tumors should also adopt the principle of combining local therapy with systemic therapy. For advanced NSCLC, especially peripheral lung cancer, local treatment should first be used to inactivate cancer cells in the mass using radiofrequency ablation to reduce the tumor load, and then systemic chemotherapy should be administered to kill the remaining metastatic For patients with mediastinal lymph nodes or other metastatic lesions, radiotherapy and other treatments can be combined. On the basis of local control of tumor, the systemic efficacy is further improved, which is of great significance in improving the survival time and quality of life of patients. In the modern treatment concept of tumor, improving the quality of survival has been paid more and more attention. Radiofrequency ablation for advanced non-small cell lung cancer is expected to open up a new way to improve the quality of survival and prolong survival for patients with advanced lung cancer because of the characteristics of minimally invasive treatment with short safe and reliable effect and less damage to the surrounding normal tissues. Since this group of treatments was performed in thoracic surgery, there is a lack of contemporaneous comparison with chemotherapy methods.