Creatinine 217μmol/L may cause uremia if not treated in time. Physiological creatinine elevation can generally be self-cured and will not develop into uremia; if it is caused by acute renal impairment, most of it can be returned to normal after active treatment and will not develop into uremia; if it is caused by chronic kidney disease, the condition progresses gradually and can eventually develop into uremia. Creatinine is a metabolite produced by muscle, which fluctuates within a certain range. Exceeding the normal value may be caused by physiological excessive protein intake or pathological inflammation, tumor and so on. Physiological can be cured by itself, but pathological may deteriorate into uremia without intervention. If the creatinine is elevated due to acute renal impairment, most of it can be normalized after active treatment and will not develop into uremia. If it is due to renal impairment caused by chronic kidney disease, the condition will progress gradually and eventually develop into uremia. It is recommended that patients with creatinine 217μmol/L should go to the hospital in time to complete the relevant examinations, to clarify the cause of the disease, and under the guidance of the doctor for symptomatic treatment.