Negative vasculitis-associated antibody is a normal result, but negative vasculitis-associated antibody does not completely exclude the possibility of vasculitis. Vasculitis-related antibodies mainly include anti-neutrophil plasma antibodies and anti-endothelial antibodies, etc. Vasculitis is characterized by inflammation and necrosis of the blood vessel wall, which can cause symptoms such as fatigue, fever, loss of body mass, purpura, numbness of the limbs, and rash, etc. Patients with suspected symptoms of vasculitis can undergo auxiliary tests including vasculitis-related antibodies in order to rule out the diagnosis. It should be noted that negative vasculitis-related antibodies such as anti-neutrophil plasma antibodies and anti-endothelial antibodies cannot completely exclude vasculitis, and the diagnosis of vasculitis is mainly based on the patient’s clinical symptoms, signs, and medical history. Laboratory test results should be interpreted by a professional physician, and it is recommended that patients with negative vasculitis-associated antibodies go to the Department of Rheumatology and Immunology of a regular hospital for detailed consultation.